Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart
نویسندگان
چکیده
منابع مشابه
ischaemic preconditioning in isolated rat heart
Objective: To assess whether the protective effect of ischaemic preconditioning (IPC) on endothelial function in coronary arteries of the rat involves prostaglandins. Methods: Isolated rat hearts perfused under constant flow conditions were exposed to 30 min of partial ischaemia (flow-rate 1 ml /min) followed by 20 min of reperfusion, after which coronaries were precontracted with U-46619 0.1 m...
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Objective: Several studies have shown that Chichorium intybus L. (C. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. Contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. The aim of the present study was to investigate the effect of aqueous extra...
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Abstract Introduction: Resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. The aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% O2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. Methods: Following 60 and 180 minutes of hyperoxia, rat hearts w...
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The MAPK family member p38 is activated in the heart after ischemia-reperfusion (I/R) injury. However, the cardioprotective vs. proapoptotic effects associated with p38 activation in the heart after I/R injury remain unresolved. Another issue to consider is that the majority of past studies have employed the rodent as a model for assessing p38's role in cardiac injury vs. protection, while the ...
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Background: It has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. However, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. Objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in is...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2001
ISSN: 0007-0912
DOI: 10.1093/bja/86.6.846